The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity (2023)

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Background: To clarify which types of cells produce interferon-γ-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients. Methods: Serum IP-10 levels were measured using enzyme-linked immunosorbent assay in 29 patients with active and 21 with inactive UC and in 20 controls. The production of IP-10 by granulocytes and monocytes adsorbed to G-1 beads was examined. In 21 active UC patients treated with granulocyte and monocyte/macrophage adsorptive apheresis (GMA), serum IP-10 levels were measured before and after treatment. IP-10-positive cells in UC mucosa were also examined immunohistochemically using tissues obtained by surgical resection and colonoscopic biopsies. Results: Serum IP-10 levels in active UC patients were significantly higher than those in inactive patients, although even in the latter the levels were increased compared with those in controls. IP-10 production by granulocytes and monocytes in active UC patients was significantly higher than that in controls. Furthermore, the number of IP-10-positive cells was elevated in the colonic mucosa of patients with active UC, and one of the main subpopulations of IP-10-positive cells was granulocytes. Serum IP-10 levels decreased following GMA treatment in responders, but not in nonresponders. Interestingly, serum IP-10 levels before GMA were higher in responders than in nonresponders. In parallel with the serum levels, IP-10-positive cells also decreased following GMA treatment. Conclusions: Serum IP-10 levels reflected UC disease activity, and the source of IP-10 was granulocytes and monocytes. Furthermore, serum IP-10 levels may be a marker for the responsiveness of patients to GMA treatment.

本文言語英語
ページ(範囲)947-956
ページ数10
ジャーナルJournal of Gastroenterology
42
12
DOI
出版ステータス出版済み - 12月 2007

ASJC Scopus 主題領域

  • 消化器病学

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Noguchi, A., Watanabe, K., Narumi, S., Yamagami, H., Fujiwara, Y., Higuchi, K., Oshitani, N., & Arakawa, T. (2007). The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity. Journal of Gastroenterology, 42(12), 947-956. https://doi.org/10.1007/s00535-007-2118-9

Noguchi, Atsushi ; Watanabe, Kenji ; Narumi, Shosaku その他. / The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity. In: Journal of Gastroenterology. 2007 ; Vol. 42, No. 12. pp. 947-956.

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title = "The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity",

abstract = "Background: To clarify which types of cells produce interferon-γ-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients. Methods: Serum IP-10 levels were measured using enzyme-linked immunosorbent assay in 29 patients with active and 21 with inactive UC and in 20 controls. The production of IP-10 by granulocytes and monocytes adsorbed to G-1 beads was examined. In 21 active UC patients treated with granulocyte and monocyte/macrophage adsorptive apheresis (GMA), serum IP-10 levels were measured before and after treatment. IP-10-positive cells in UC mucosa were also examined immunohistochemically using tissues obtained by surgical resection and colonoscopic biopsies. Results: Serum IP-10 levels in active UC patients were significantly higher than those in inactive patients, although even in the latter the levels were increased compared with those in controls. IP-10 production by granulocytes and monocytes in active UC patients was significantly higher than that in controls. Furthermore, the number of IP-10-positive cells was elevated in the colonic mucosa of patients with active UC, and one of the main subpopulations of IP-10-positive cells was granulocytes. Serum IP-10 levels decreased following GMA treatment in responders, but not in nonresponders. Interestingly, serum IP-10 levels before GMA were higher in responders than in nonresponders. In parallel with the serum levels, IP-10-positive cells also decreased following GMA treatment. Conclusions: Serum IP-10 levels reflected UC disease activity, and the source of IP-10 was granulocytes and monocytes. Furthermore, serum IP-10 levels may be a marker for the responsiveness of patients to GMA treatment.",

keywords = "Adsorptive apheresis, Granulocyte, IP-10, Monocyte, Ulcerative colitis",

author = "Atsushi Noguchi and Kenji Watanabe and Shosaku Narumi and Hirokazu Yamagami and Yasuhiro Fujiwara and Kazuhide Higuchi and Nobuhide Oshitani and Tetsuo Arakawa",

year = "2007",

month = dec,

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doi = "10.1007/s00535-007-2118-9",

language = "英語",

volume = "42",

pages = "947--956",

journal = "Journal of Gastroenterology",

issn = "0944-1174",

publisher = "Springer Japan",

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}

Noguchi, A, Watanabe, K, Narumi, S, Yamagami, H, Fujiwara, Y, Higuchi, K, Oshitani, N & Arakawa, T 2007, 'The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity', Journal of Gastroenterology, vol. 42, no. 12, pp. 947-956. https://doi.org/10.1007/s00535-007-2118-9

The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity. / Noguchi, Atsushi; Watanabe, Kenji; Narumi, Shosaku その他.
In: Journal of Gastroenterology, Vol. 42, No. 12, 12.2007, p. 947-956.

研究成果: ジャーナルへの寄稿学術論文査読

TY - JOUR

T1 - The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity

AU - Noguchi, Atsushi

AU - Watanabe, Kenji

AU - Narumi, Shosaku

AU - Yamagami, Hirokazu

AU - Fujiwara, Yasuhiro

AU - Higuchi, Kazuhide

AU - Oshitani, Nobuhide

AU - Arakawa, Tetsuo

PY - 2007/12

Y1 - 2007/12

N2 - Background: To clarify which types of cells produce interferon-γ-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients. Methods: Serum IP-10 levels were measured using enzyme-linked immunosorbent assay in 29 patients with active and 21 with inactive UC and in 20 controls. The production of IP-10 by granulocytes and monocytes adsorbed to G-1 beads was examined. In 21 active UC patients treated with granulocyte and monocyte/macrophage adsorptive apheresis (GMA), serum IP-10 levels were measured before and after treatment. IP-10-positive cells in UC mucosa were also examined immunohistochemically using tissues obtained by surgical resection and colonoscopic biopsies. Results: Serum IP-10 levels in active UC patients were significantly higher than those in inactive patients, although even in the latter the levels were increased compared with those in controls. IP-10 production by granulocytes and monocytes in active UC patients was significantly higher than that in controls. Furthermore, the number of IP-10-positive cells was elevated in the colonic mucosa of patients with active UC, and one of the main subpopulations of IP-10-positive cells was granulocytes. Serum IP-10 levels decreased following GMA treatment in responders, but not in nonresponders. Interestingly, serum IP-10 levels before GMA were higher in responders than in nonresponders. In parallel with the serum levels, IP-10-positive cells also decreased following GMA treatment. Conclusions: Serum IP-10 levels reflected UC disease activity, and the source of IP-10 was granulocytes and monocytes. Furthermore, serum IP-10 levels may be a marker for the responsiveness of patients to GMA treatment.

AB - Background: To clarify which types of cells produce interferon-γ-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients. Methods: Serum IP-10 levels were measured using enzyme-linked immunosorbent assay in 29 patients with active and 21 with inactive UC and in 20 controls. The production of IP-10 by granulocytes and monocytes adsorbed to G-1 beads was examined. In 21 active UC patients treated with granulocyte and monocyte/macrophage adsorptive apheresis (GMA), serum IP-10 levels were measured before and after treatment. IP-10-positive cells in UC mucosa were also examined immunohistochemically using tissues obtained by surgical resection and colonoscopic biopsies. Results: Serum IP-10 levels in active UC patients were significantly higher than those in inactive patients, although even in the latter the levels were increased compared with those in controls. IP-10 production by granulocytes and monocytes in active UC patients was significantly higher than that in controls. Furthermore, the number of IP-10-positive cells was elevated in the colonic mucosa of patients with active UC, and one of the main subpopulations of IP-10-positive cells was granulocytes. Serum IP-10 levels decreased following GMA treatment in responders, but not in nonresponders. Interestingly, serum IP-10 levels before GMA were higher in responders than in nonresponders. In parallel with the serum levels, IP-10-positive cells also decreased following GMA treatment. Conclusions: Serum IP-10 levels reflected UC disease activity, and the source of IP-10 was granulocytes and monocytes. Furthermore, serum IP-10 levels may be a marker for the responsiveness of patients to GMA treatment.

KW - Adsorptive apheresis

KW - Granulocyte

KW - IP-10

KW - Monocyte

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KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=37549016755&partnerID=8YFLogxK

U2 - 10.1007/s00535-007-2118-9

DO - 10.1007/s00535-007-2118-9

M3 - 学術論文

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AN - SCOPUS:37549016755

SN - 0944-1174

VL - 42

SP - 947

EP - 956

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

IS - 12

ER -

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Noguchi A, Watanabe K, Narumi S, Yamagami H, Fujiwara Y, Higuchi K その他. The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity. Journal of Gastroenterology. 2007 12月;42(12):947-956. doi: 10.1007/s00535-007-2118-9

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